GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| BLCA | cis | rs60843830 | 1 | rs58461606 | chr2:267367 | SH3YL1 | chr2:218138-264810:- | -0.44 | -11.68 | 3.47E-27 | Spherical equivalent (joint main effects and education interaction) |
| BLCA | cis | rs9309473 | 1 | rs58603761 | chr2:73726605 | ALMS1P | chr2:73872046-73912692:+ | 0.39 | 5.84 | 1.13E-8 | Metabolite levels |
| BLCA | cis | rs2243480 | 1 | rs58669269 | chr7:65951953 | CCT6P1 | chr7:65216092-65228661:+ | 0.37 | 4.81 | 2.22E-6 | Diabetic kidney disease |
| BLCA | cis | rs7714584 | 1 | rs58717741 | chr5:150284936 | LOC134466 | chr5:150310000-150326146:- | 0.54 | 7.08 | 7.06E-12 | Crohn's disease |
| BLCA | cis | rs7112513 | 1 | rs588918 | chr11:116856642 | PCSK7 | chr11:117075789-117102811:- | -0.32 | -4.28 | 2.32E-5 | Protein quantitative trait loci |
| BLCA | cis | rs1109114 | 1 | rs59032271 | chr5:148618749 | AFAP1L1 | chr5:148651401-148721365:+ | 0.27 | 5.02 | 8.06E-7 | Body mass index |
| BLCA | cis | rs7714584 | 1 | rs59043558 | chr5:150334662 | LOC134466 | chr5:150310000-150326146:- | 0.52 | 5.93 | 6.83E-9 | Crohn's disease |
| BLCA | cis | rs9783347 | 1 | rs59150578 | chr11:18340862 | GTF2H1 | chr11:18343816-18388590:+ | 0.32 | 6.04 | 3.61E-9 | Pancreatic cancer |
| BLCA | cis | rs1930961 | 1 | rs59226697 | chr22:25870037 | CRYBB2 | chr22:25615612-25627836:+ | 0.99 | 8.03 | 1.23E-14 | Bipolar disorder with mood-incongruent psychosis |
| BLCA | cis | rs59227481 | 1 | rs59227481 | chr12:110007993 | KCTD10 | chr12:109886460-109915155:- | -0.21 | -3.93 | 9.97E-5 | Age-related nuclear cataracts |
| BLCA | cis | rs344081 | 1 | rs59244547 | chr3:156582997 | LEKR1 | chr3:156544076-156763918:+ | -0.47 | -6.39 | 4.95E-10 | Bone mineral density |
| BLCA | cis | rs9902453 | 1 | rs59274738 | chr17:28437635 | EFCAB5 | chr17:28256874-28435469:+ | 0.23 | 3.91 | 0.000108 | Coffee consumption (cups per day) |
| BLCA | cis | rs11574514 | 1 | rs59376497 | chr16:67681170 | LRRC36 | chr16:67360747-67419108:+ | 0.59 | 4.35 | 1.72E-5 | Crohn's disease |
| BLCA | cis | rs6684514 | 1 | rs59468948 | chr1:156288058 | BGLAP | chr1:156182784-156213112:+ | 0.23 | 3.86 | 0.000132 | Mean corpuscular hemoglobin concentration;Glycated hemoglobin levels |
| BLCA | cis | rs7714584 | 1 | rs59531858 | chr5:150247063 | LOC134466 | chr5:150310000-150326146:- | 0.54 | 6.52 | 2.24E-10 | Crohn's disease |